Related Experiment Video
Updated: Apr 25, 2026
Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces
Published on: December 6, 2024
Photoelectron-Triggered Immunomodulation: Spray-Modified Titanium Implants Promote Macrophage M2 Polarization and
Shuqi Feng1, Junyu Dong2, Lixuan Huang1
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14th, 3rd Section, Renmin South Road, Chengdu 610041, China.
This study introduces a novel near-infrared (NIR)-responsive titanium implant surface that uses photoelectronic immunomodulation. This advanced surface enhances bone integration by controlling macrophage responses, improving implant success rates.
Area of Science:
- Biomaterials Science
- Immunology
- Orthopedic Surgery
Background:
- Osteoimmune homeostasis is crucial for titanium implant osseointegration.
- Current surface strategies lack dynamic responsiveness to the changing microenvironment after surgery.
- Compromised regulation hinders successful bone-implant integration.
Purpose of the Study:
- To develop a dynamic, near-infrared (NIR)-responsive biointerface for improved osseointegration.
- To achieve noninvasive control of macrophage polarization using photoelectronic immunomodulation.
- To enhance the bone-implant interface regulation.
Main Methods:
- Fabrication of a NIR-responsive biointerface using ultrasonic spray deposition of gold/rare earth nanocomposites (Au@RE) on sandblasted acid-etched titanium (SLA Ti).
- Characterization of nanocomposite synthesis and photoelectric properties using XRD, TEM, and phototransient spectra.
- In vitro and in vivo evaluations of macrophage polarization and osteogenic differentiation, and osseointegration in a mouse model.
Main Results:
- Successful synthesis of Yb/Er-doped NaYF4 coating with Au nanoparticles (Au@RE) exhibiting photoelectric properties under NIR irradiation.
- NIR-activated photoelectronic signals effectively induced M2 macrophage polarization in vitro.
- Enhanced M2 macrophage infiltration and accelerated bone formation observed in vivo, leading to significantly improved osseointegration with Au@RE/SLA Ti compared to conventional SLA Ti.
Conclusions:
- The developed NIR-responsive biointerface enables dynamic regulation of the bone-implant interface via photoelectronic immunomodulation.
- This approach offers a promising strategy for enhancing titanium implant osseointegration by modulating the osteoimmune response.
- Ultrasonic spray fabrication combined with photoelectronic immunomodulation provides a foundation for next-generation implantable biomaterials.
