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Exploring the Relationship Between Colitis-Associated Cancer and Lipid Metabolism Reprogramming from the Perspective
ShuangShuang Zhang1, Kunshan Li2,3, Dong-Dong Yu4
1Shanghai Chest Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200030, People's Republic of China.
Journal of Inflammation Research
|April 24, 2026
Summary
Aberrant lipid metabolism fuels colitis-associated colorectal cancer (CAC) by altering the tumor microenvironment and immune response. Targeting lipid reprogramming offers new therapeutic strategies for this severe inflammatory bowel disease complication.
Area of Science:
- Oncology
- Gastroenterology
- Metabolic Research
Background:
- Colitis-associated colorectal cancer (CAC) is a severe complication of inflammatory bowel disease (IBD) with poor prognosis.
- Aberrant lipid metabolism is increasingly recognized as a driver of CAC progression.
- Specific metabolic rewiring during chronic colitis leading to malignancy remains underexplored.
Purpose of the Study:
- To dissect the synergistic interactions between lipid metabolism and inflammation, immune microenvironment, and gut dysbiosis in CAC.
- To identify key genes and therapeutic targets in lipid metabolism for CAC.
- To investigate the translational value of targeting lipid metabolic reprogramming in CAC.
Main Methods:
- Systematic review and analysis of current evidence on lipid metabolism in CAC.
- Dissection of the dynamic transition toward malignancy from a metabolic viewpoint.
- Integration of findings on inflammation, immune microenvironment, and intestinal dysbiosis.
Main Results:
- Aberrant lipid metabolism fuels CAC by providing energy, disrupting tumor microenvironment homeostasis, and promoting immune escape.
- A vicious cycle of metabolism-inflammation-carcinogenesis is established.
- Key genes and potential therapeutic targets governing lipid metabolism in CAC have been identified.
Conclusions:
- Lipid reprogramming orchestrates the inflammation-to-cancer shift in CAC.
- Targeting lipid metabolic reprogramming holds translational value for early intervention and combination therapies in CAC.
- Novel research insights and therapeutic strategies can improve clinical prognosis for CAC patients.
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