From laboratory to real-world exposure: correlating cosmetic patch test results with large-scale consumer safety data
Kai Yang1,2, Qin Zhang1,2, Dangdang Cheng1,2
1Shanghai Jiyan Biomedical Development Co., Ltd., Shanghai, China.
Background:
Limited research exists on revealing the correlation between laboratory safety tests and real-world safety feedback from consumers of cosmetics.
Objective:
To establish cosmetovigilance by associating patch test results with consumer-reported adverse reaction (CRARs) feedback form e-commerce feedback for cosmetics targeting sensitive skin.
Methods:
Patch tests were performed on a cohort of sensitive-skin cosmetics, and CRARs were extracted from e-commerce comments. A generalized linear model was utilized to analyze the association between patch test results and CRARs, considering functional claims and application modes.
Results:
Among the patch test results of 64 cosmetics, 42 exhibited negative reactions, 21 showed doubtful reactions, and one cosmetic demonstrated a weak positive reaction. The model established with a warning threshold of two doubtful reactions proved to be optimal. Patch test results were associated with sensitization-related and pain-related CRARs, but not with acnegenic-related CRARs. Brightening and acne treatment cosmetics exhibited higher acnegenic and pain rates, while leave-on cosmetics had a higher sensitization rate.
Conclusion:
The data-driven results show that cosmetics with 2 or more doubtful reactions in patch test have a significantly correlation with real-world CRARs, which reminds relevant practitioners to be more cautious about doubtful reactions in patch test.
More Related Videos
11:07Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
07:05Correlative Optical Spectroscopy and Mass Spectrometry Imaging Methodology to Visualise Drug Distribution in a Soft Tissue Section
Published on: June 20, 2025
Related Concept Videos
Drug Product Performance: In Vitro–In Vivo Correlation
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Toxicity Testing in Animals
