Related Experiment Video
Updated: Apr 25, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Impact of early enteral nutrition after transit reconstruction in pediatrics
M Sáenz Molina1, M Fanjul Gómez1, S Monje Fuente1
1Pediatric Surgery Department. Hospital Universitario Gregorio Marañón. Madrid (Spain).
Insights
Early enteral nutrition in pediatric surgery patients speeds intestinal transit and reduces hospital stays without increasing complications. Further multicenter studies are needed to confirm these findings for pediatric intestinal continuity restoration.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Clinical Nutrition
Background:
- Restoring intestinal continuity is common in pediatric surgery, but optimal timing for postoperative enteral nutrition remains debated.
- Traditional delayed nutrition aims to prevent complications, while adult studies suggest early feeding benefits.
- Limited pediatric evidence exists on early versus late enteral nutrition after intestinal reconstruction.
Purpose of the Study:
- To evaluate the safety and clinical outcomes of early versus late enteral nutrition in pediatric patients undergoing intestinal continuity restoration.
- To compare complication rates, time to intestinal transit recovery, and hospital stay between early and late feeding groups.
Main Methods:
- Prospective, single-center study of 43 pediatric patients (2018-2025).
- Comparison of two groups: early oral enteral nutrition (6 hours post-op) vs. late nutrition.
- Analysis of demographic variables, ostomy type, intestinal transit recovery, complications, epidural analgesia duration, and hospital stay.
Main Results:
- No significant difference in overall complication rates between early and late enteral nutrition groups.
- Early enteral feeding was associated with an earlier recovery of intestinal transit (p=0.002).
- Patients receiving early enteral nutrition experienced a significant reduction in hospital stay (p=0.04).
Conclusions:
- Early oral enteral nutrition post-intestinal reconstruction in pediatric patients is safe and effective.
- It leads to faster intestinal transit restoration and shorter hospital stays without increased complications.
- Larger, multicenter studies are recommended to validate these findings and inform clinical guidelines.
Introduction:
Restoration of intestinal continuity is a common procedure in pediatric surgery. However, controversy persists regarding the optimal timing for initiating postoperative enteral nutrition. Although traditionally a delayed start has been recommended to reduce the risk of complications such as anastomotic leak or paralytic ileus, recent studies in adult populations suggest benefits of early initiation. Evidence in the pediatric population is limited. This study evaluates the safety and clinical outcomes of early versus late enteral nutrition in children undergoing intestinal continuity restoration.
Material And Methods:
Prospective, single-center study with 43 pediatric patients operated between 2018 and 2025. Two groups were compared: early enteral nutrition via oral route (6 hours after surgery) and late nutrition. Demographic variables, type of ostomy, time to recovery of intestinal transit, postoperative complications, duration of epidural analgesia, and length of hospital stay were analyzed.
Results:
No differences were observed in the overall complication rate between the groups. Patients who received early enteral feeding showed an earlier start of intestinal transit (p= 0.002) and a significant reduction in hospital stay (p= 0.04).
Conclusions:
The early initiation of oral enteral nutrition after intestinal transit reconstruction in pediatric patients was associated with a shorter time until the restoration of intestinal transit and a reduction in hospital stay, with no observed increase in the incidence of complications. However, multicenter studies with a larger sample size are needed to confirm these findings and establish more robust recommendations.
Related Concept Videos
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Enteral Nutrition I: Orogastric and Nasogastric Feeding
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical Interventions for Peptic Ulcer Disease
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...

