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Published on: February 21, 2021
[Astrocytes and sleep: from genes to networks]
1Interactions neurogliales dans la physiologie et les maladies cérébrales, Centre de recherche interdisciplinaire en biologie, Collège de France, CNRS UMR 7241, INSERM U1050, Université PSL, PSL-NEURO, Paris, France.
None:
Astrocytes are glial cells of the central nervous system that play key roles in regulating synaptic activity and sleep. Recent advances in genetic engineering, neuroimaging, and molecular biology have provided new insights into astrocytic functions. This review highlights the various mechanisms through which astrocytes regulate sleep, including transcriptomic and morphological changes, as well as gliotransmission. A better understanding of these astrocyte-dependent processes in sleep physiology will refine current models of sleep regulation and may open new avenues for sleep-targeted therapies.
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