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Related Experiment Video

Updated: Apr 25, 2026

Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
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Real-time planar angiographic cerebral perfusion imaging.

Suam Kim1, Andrea Kronfeld2, Sebastian R Reder2

  • 1Department of Neuroradiology, University Medical Centre Mainz, Johannes Gutenberg University, Mainz, Germany. suam.kim@unimedizin-mainz.de.

International Journal of Computer Assisted Radiology and Surgery
|April 24, 2026
PubMed
Summary

This study introduces a new setup for real-time cerebral perfusion imaging using Digital Subtraction Angiography (DSA). This innovation allows for rapid, on-the-fly analysis of angiograms, improving diagnostic capabilities in clinical settings.

Keywords:
Artificial intelligenceCerebral perfusionDigital subtraction angiographyStroke

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Area of Science:

  • Medical Imaging
  • Interventional Radiology
  • Neurology

Background:

  • Digital Subtraction Angiography (DSA) is crucial for minimally invasive procedures.
  • Enhancing DSA with tomographic methods like 3D reconstruction and CT perfusion imaging improves diagnostic value.

Purpose of the Study:

  • To demonstrate a hardware and software setup for expanding DSA capabilities to functional perfusion imaging.
  • To assess planar cerebral perfusion in real-time during angiographic procedures.

Main Methods:

  • Utilized an HDMI video splitter and frame-grabber to duplicate DSA video output.
  • Applied numerical approximation and neural network inference for perfusion parameter map generation.
  • Compared completion times of various perfusion estimation methods.

Main Results:

  • Identified two perfusion estimation methods (SVD-based deconvolution, numerical curve feature estimation) yielding results in 1-2 seconds.
  • Optimized conventional curve fitting to reduce calculation time from five minutes to 30 seconds.
  • Achieved clinically feasible real-time cerebral perfusion evaluation.

Conclusions:

  • Direct access to image data outside the angiography suite enables real-time cerebral perfusion evaluation.
  • On-the-fly analysis of angiograms is now possible in clinical settings.
  • Facilitates future clinical studies on angiographic perfusion.