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Uromodulin as a protein and genetic biomarker for hypertension: A detailed systematic review and meta-analysis

Hash Brown Taha1, Nandhana Vivek2, Samuel Ogunsanya3

  • 1Washington University in St. Louis, St. Louis, USA.

The American Journal of Medicine
|April 24, 2026
PubMed

Insights

Uromodulin is not a clinically useful biomarker for hypertension, according to a meta-analysis. Further research may explore its potential for predicting other cardiovascular outcomes.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarker Discovery

Background:

  • Hypertension is a leading global cause of cardiovascular disease.
  • There is a need for better biomarkers to manage hypertension.
  • Uromodulin is associated with kidney function and blood pressure regulation.

Purpose of the Study:

  • To systematically review and perform a meta-analysis on uromodulin as a biomarker for hypertension.
  • To evaluate the clinical utility of uromodulin protein and genetic variants in hypertension.

Main Methods:

  • Systematic review and meta-analysis of 35 human studies.
  • Inclusion of studies on uromodulin protein levels and genome-wide association studies (GWAS) related to hypertension.
  • Analysis using inverse variance weighted random effects models and assessment of publication bias.

Main Results:

  • Uromodulin did not show clinically significant utility as a biomarker for hypertension or related outcomes across diagnostic, prognostic, and predictive studies.
  • Analysis included data from 10,726 individuals with hypertension and 8,762 controls for protein levels.
  • GWAS included over 450,000 hypertension cases and 150,000 controls.

Conclusions:

  • Uromodulin is not a clinically useful protein or genetic biomarker for hypertension.
  • Uromodulin may retain potential for predicting other cardiovascular outcomes.
Abstract

Keywords:
biomarkercardiovasculardiagnostichypertensionnephrology

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