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Updated: Apr 26, 2026

Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques

Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques

Published on: April 22, 2010

Customized Open Patch Allergen Testing in a Rhesus Macaque (Macaca mulatta).

Jeffrey S Frankel^1,2, Kevin M O'Brien^1,2, Leah Makaron^1,2

¹1University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, Pennsylvania; and.

Journal of the American Association for Laboratory Animal Science : JAALAS

|April 24, 2026

Summary

This summary is machine-generated.

A rhesus macaque experienced chronic skin issues resolved by identifying a dish soap allergen through patch testing. This method shows promise for diagnosing contact dermatitis in laboratory animals.

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Published on: December 15, 2011

Area of Science:

Veterinary Dermatology
Primate Medicine
Allergology

Background:

Chronic dermatitis and alopecia are common in laboratory animals.
Standard treatments are often ineffective for complex cases.
Identifying environmental allergens is crucial for effective management.

Purpose of the Study:

To report the successful use of customized open patch allergen testing.
To identify a specific contact allergen in a rhesus macaque with refractory dermatitis.
To highlight the diagnostic utility of patch testing in nonhuman primates.

Main Methods:

A comprehensive dermatologic workup was performed on an adult rhesus macaque.
A customized open patch allergen testing protocol was applied to assess environmental exposures.
Clinical signs and response to allergen removal were monitored.

Main Results:

Patch testing identified a commercial dish soap as the causative contact allergen.
Discontinuation of the dish soap led to complete and sustained resolution of dermatitis and alopecia.
Clinical signs recurred upon accidental reintroduction of the soap.

Conclusions:

Customized open patch allergen testing is effective in diagnosing contact allergens in nonhuman primates.
This diagnostic approach can resolve refractory dermatitis and alopecia in laboratory animals.
Patch testing represents a valuable tool for veterinary dermatologists in laboratory animal medicine.