Landau-Kleffner Syndrome with Adult-onset Epilepsy: A Case Report

This case report describes Landau-Kleffner syndrome (LKS) with adult-onset epilepsy in a 33-year-old man with preexisting developmental delay. We outline the clinical presentation, including language regression and seizures, and address the diagnostic challenges. The case highlights the importance of considering LKS in case of adult-onset epilepsy and underscores the critical role of electroencephalography, particularly the presence of continuous spike-wave activity during sleep. We also review the treatment options of LKS with adult-onset epilepsy, with the focus on the effectiveness of levetiracetam. An atypical finding of right hippocampal sclerosis on brain magnetic resonance imaging is also noted. This case contributes to the limited literature on LKS with adult-onset epilepsy and emphasizes the need for further research.