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Landau-Kleffner Syndrome with Adult-onset Epilepsy: A Case Report.
1Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
This case report details Landau-Kleffner syndrome (LKS) in an adult, presenting with epilepsy and language regression. Early diagnosis via EEG and treatment with levetiracetam are crucial for managing this rare neurological disorder.
Area of Science:
- Neurology
- Clinical Case Reports
Background:
- Landau-Kleffner syndrome (LKS) is a rare disorder characterized by acquired epileptic aphasia.
- Adult-onset LKS is exceptionally uncommon, posing diagnostic challenges.
Purpose of the Study:
- To describe a case of adult-onset LKS with epilepsy in a patient with prior developmental delay.
- To highlight diagnostic considerations and treatment strategies for adult LKS.
Main Methods:
- Case report of a 33-year-old male with language regression and seizures.
- Electroencephalography (EEG) demonstrating continuous spike-wave activity during sleep.
- Magnetic Resonance Imaging (MRI) of the brain.
Main Results:
- The patient presented with adult-onset epilepsy and significant language regression.
- EEG confirmed continuous spike-wave activity during sleep, characteristic of LKS.
- Brain MRI revealed atypical right hippocampal sclerosis.
Conclusions:
- Adult-onset epilepsy should prompt consideration of LKS, especially with language regression.
- Continuous spike-wave activity during sleep on EEG is a key diagnostic marker for LKS.
- Levetiracetam showed potential effectiveness in treating adult-onset LKS with epilepsy.
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