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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

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Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
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The Oral Microbiota01:27

The Oral Microbiota

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The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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Other Pulmonary Disorders01:17

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Teeth01:15

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Association Between Obstructive Sleep Apnea and Periodontitis: A Systematic Umbrella Review.

Mohammed Khalid Mahmood1, Shahen Hiwa Omer2, Sarhang Sarwat Gul3,4

  • 1College of Dentistry, Sulaymaniyah University, Sulaymaniyah, Iraq.

Clinical and Experimental Dental Research
|April 26, 2026
PubMed
Summary
This summary is machine-generated.

Obstructive sleep apnea (OSA) is significantly linked to periodontitis. Severe OSA shows a stronger association, highlighting the need for further research into their interconnectedness and treatment implications.

Keywords:
meta‐analysisobstructive sleep apneaperiodontitissleep disorderssystematic review

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Area of Science:

  • Oral Health
  • Sleep Medicine
  • Epidemiology

Background:

  • Obstructive sleep apnea (OSA) is a prevalent condition characterized by repeated episodes of airway obstruction during sleep.
  • Periodontitis is a chronic inflammatory disease affecting the gums and supporting structures of the teeth.
  • Emerging evidence suggests a potential link between OSA and periodontitis, warranting further investigation.

Purpose of the Study:

  • To conduct an umbrella meta-analysis evaluating the association between obstructive sleep apnea (OSA) and periodontitis.
  • To synthesize findings from existing meta-analyses to provide a comprehensive overview of the current evidence.

Main Methods:

  • A systematic search of multiple databases (PubMed, MEDLINE, Web of Science, Scopus, Embase, Google Scholar) was performed.
  • Meta-analyses reporting odds ratios (OR) for the OSA-periodontitis association were included.
  • Methodological quality (AMSTAR-2) and certainty of evidence (GRADE) were assessed; random-effects meta-analysis and publication bias analyses (Egger's test, trim-and-fill) were conducted.

Main Results:

  • Seven meta-analyses with over 225,000 participants confirmed a significant association between OSA and periodontitis (OR 1.96).
  • The association strengthened after adjusting for publication bias (OR 2.24), with severe OSA showing higher odds (OR 2.25) than mild-moderate OSA (OR 1.82).
  • Low certainty of evidence was noted due to substantial heterogeneity and publication bias; a high overlap ratio (26.8%) among included meta-analyses was observed.

Conclusions:

  • A significant association exists between obstructive sleep apnea and periodontitis, with severe OSA demonstrating a more pronounced link.
  • Future research should explore the bidirectional impact of periodontal therapy on OSA severity and vice versa.
  • The findings underscore the importance of considering oral health in the management of OSA patients and vice versa.