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Sarcopenia status among treatment-naïve gastric cancer patients in China: A cross-sectional study
Kai-Qiang Xie1, Lu-Jia Zhou2, Wan Feng3
1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China; Department of Pharmacy, The Third Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330008, China.
Background:
Due to the lack of uniform diagnostic criteria and the exclusive use of computed tomography as an indicator, the prevalence of sarcopenia in patients with stomach cancer varies considerably. Currently, limited data are available from comprehensive studies utilizing bioelectrical impedance analysis (BIA) for muscle mass, combined with handgrip strength and gait speed, to assess sarcopenia in treatment-naïve gastric cancer patients. Therefore, this study aims to investigate this condition among treatment-naïve gastric cancer patients in China.
Objective:
This study aimed to assess the prevalence of Chinese sarcopenia in treatment‑naïve gastric cancer patients by using BIA with handgrip strength and gait speed, in line with the standard Chinese Guidelines for the Diagnosis and Treatment of Sarcopenia.
Methods:
Employing a single-center cross-sectional design, this study assessed the prevalence of sarcopenia in treatment-naïve gastric cancer patients using BIA and standard Chinese diagnostic criteria. Additionally, comparative analyses of body composition and laboratory parameters were conducted to discern significant differences between patients with and without sarcopenia.
Results:
Using Chinese diagnostic criteria and BIA, we identified a sarcopenia prevalence of 17.49% in treatment-naïve gastric cancer patients. This cohort demonstrated significant muscle and fat depletion alongside a 62.68% prevalence of GLIM-defined malnutrition. Additionally, sarcopenia was associated with a higher risk of anemia and significantly reduced serum albumin and total protein levels relative to patients without the condition.
Conclusions:
Sarcopenia imposes a significant clinical burden on Chinese patients recently diagnosed with gastric cancer, and is frequently associated with severe malnutrition and anaemia.
