Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

1.2K
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.2K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

880
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
880
Panic Disorder01:27

Panic Disorder

1.2K
Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
1.2K
Depression: Overview01:18

Depression: Overview

1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

2.0K
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
2.0K
Bipolar Disorder01:30

Bipolar Disorder

1.4K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unusual Presentation of Nephroblastoma in an Adolescent: A Case of Initial Misdiagnosis as a Renal Abscess.

Cureus·2025
Same author

Rising mortality in cerebral atherosclerosis-related deaths in the United States (1999-2020): a 21-year retrospective analysis of CDC-WONDER database.

Annals of medicine and surgery (2012)·2025
Same author

Kinematic limitations during stair ascent and descent in patients with adult spinal deformity.

Brain & spine·2025
Same author

Digital Psychiatry: Opportunities, Challenges, and Future Directions.

Journal of psychiatric practice·2024
Same author

Imetelstat (Rytelo): a promising treatment for adults with lower-risk MDS and transfusion-dependent anemia.

Annals of medicine and surgery (2012)·2024
Same author

Elafibranor (Iqirvo) unveiled: a groundbreaking FDA-approved therapy revolutionizing primary biliary cholangitis treatment.

Annals of medicine and surgery (2012)·2024

Related Experiment Video

Updated: Apr 28, 2026

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats
09:07

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats

Published on: February 23, 2015

13.3K

Gender Differences and Comorbidities in Major Depression.

Mohamad Jaber1, Hamza Kahwaji2, Dany Eid1

  • 1Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Advances in Experimental Medicine and Biology
|April 26, 2026
PubMed
Summary

Major depressive disorder (MDD) affects millions globally. This review explores significant gender differences in MDD rates, presentation, and comorbidities, aiming to improve diagnosis and treatment.

Keywords:
ComorbiditiesDepressionGender differencesMajor depressive disorderMood disorder

More Related Videos

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

2.8K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.8K

Related Experiment Videos

Last Updated: Apr 28, 2026

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats
09:07

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats

Published on: February 23, 2015

13.3K
Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

2.8K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.8K

Area of Science:

  • Psychiatry
  • Neuroscience
  • Public Health

Background:

  • Major depressive disorder (MDD) is a prevalent psychiatric condition impacting global health.
  • MDD is characterized by persistent sadness, anhedonia, weight changes, sleep disturbances, fatigue, and worthlessness.
  • Severe MDD can lead to functional impairment and suicidal ideation.

Purpose of the Study:

  • To examine gender differences in the occurrence, clinical presentation, and comorbidities of MDD.
  • To explore biological, psychological, and sociocultural factors contributing to the observed gender disparity in depression rates.
  • To enhance clinical practice and inform the development of gender-specific treatment strategies for MDD.

Main Methods:

  • Literature review of existing research on gender differences in MDD.
  • Analysis of clinical characteristics and risk factors associated with MDD across genders.
  • Synthesis of findings to identify gaps in current understanding and guide future research.

Main Results:

  • Females exhibit higher rates of MDD compared to males.
  • Significant gender-based variations exist in MDD presentation and associated comorbidities.
  • Multiple biological, psychological, and sociocultural factors contribute to the gender gap in depression.

Conclusions:

  • Understanding gender differences in MDD is crucial for accurate diagnosis, effective treatment, and improved prognosis.
  • Further research is needed to fully elucidate the complexities of the gender gap in MDD.
  • Developing gender-specific interventions holds promise for better managing MDD and supporting affected individuals.