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Updated: Apr 28, 2026
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Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
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Emerging Therapeutic Interventions for Treatment‑Resistant Depression.
Marcela Carbajal Tamez1, Giselli Scaini2, Joao Quevedo2
1Center for Interventional Psychiatry, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth Houston), Houston, TX, USA. Marcela.C.CarbajalTamez@uth.tmc.edu.
Advances in Experimental Medicine and Biology
|April 26, 2026
Summary
Treatment-resistant depression (TRD) requires novel strategies beyond traditional monoaminergic targets. Experimental developments show promise for new TRD management, focusing on precision psychiatry and computational tools.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Treatment-resistant depression (TRD) is a significant clinical challenge.
- TRD presents a distinct neurobiological syndrome within affective disorders.
- Current pharmacotherapy primarily targets monoaminergic systems.
Purpose of the Study:
- To outline progress in therapeutic strategies for TRD.
- To highlight translational models, precision psychiatry, and computational tools.
- To disseminate promising experimental developments for TRD management.
Main Methods:
- Review of translational models.
- Analysis of precision psychiatry approaches.
- Exploration of computational tools in TRD research.
Main Results:
- Growing mechanistic insights into TRD beyond monoaminergic systems.
- Feasibility of precision interventions is increasing.
- Experimental developments show promise in preclinical studies.
Conclusions:
- Novel therapeutic strategies for TRD are emerging.
- Precision interventions face constraints in clinical trial design and access.
- Further research into experimental developments is needed to inspire new TRD management strategies.
Keywords:
DepressionExperimentalMajor Depressive DisorderNovel InterventionsPersonalized MedicineTreatment-Resistant DepressionMore Related Videos
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