Outcomes for acute myocardial infarction with supranormal left ventricular ejection fraction
Seok Oh1, Ju Han Kim1,2, Kyung Hoon Cho1,2,3
1Department of Cardiology, Chonnam National University Hospital, Gwangju, Republic of Korea.
Frontiers in Cardiovascular Medicine
|April 27, 2026
Summary
Patients with acute myocardial infarction (AMI) and supranormal left ventricular ejection fraction (snLVEF) have the best outcomes. This study found lower 3-year mortality in the snLVEF group compared to normal LVEF.
Area of Science:
- Cardiology
- Clinical Outcomes Research
Background:
- Evidence suggests acute myocardial infarction (AMI) with normal left ventricular ejection fraction (LVEF) yields better outcomes than reduced LVEF.
- Real-world data on AMI patients with supranormal LVEF (snLVEF) is limited.
Purpose of the Study:
- To investigate the clinical outcomes, specifically 3-year all-cause mortality, in patients experiencing AMI with snLVEF.
Main Methods:
- A cohort of 27,903 AMI patients was analyzed from a Korean nationwide registry (November 2011-June 2020).
- Patients were stratified into four LVEF groups: snLVEF (≥65%), normal (50%-64%), mid-range (40%-49%), and reduced (<40%).
- Cox proportional hazards models were used to assess associations with 3-year all-cause mortality.
Main Results:
- The supranormal LVEF group demonstrated significantly lower 3-year all-cause mortality compared to the normal LVEF group.
- Hazard ratios (HR) in fully adjusted models indicated a protective effect of snLVEF (HR 0.77; 95% CI 0.60-0.98).
Conclusions:
- Patients with AMI and snLVEF exhibit the most favorable clinical outcomes.
- snLVEF is associated with the lowest mortality rates among AMI patient subgroups.
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