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Concept of 2D van der Waals Nanohybrids for Key Biomedical Applications
N Sanoj Rejinold1,2, Jin-Ho Choy1,3
1Intelligent Nanohybrid Materials Laboratory (INML), Department of Chemistry, College of Science and Technology, Dankook University, Cheonan, 31116, Republic of Korea.
International Journal of Nanomedicine
|April 27, 2026
Summary
Two-dimensional (2D) van der Waals (vdW) nanohybrids offer modular integration of diverse functions for advanced nanomedicine. These materials enable synergistic therapeutic and diagnostic applications by combining distinct 2D layers.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- 2D nanomaterials have evolved from single sheets to complex van der Waals (vdW) nanohybrids.
- These hybrids utilize weak interlayer forces for modular assembly of chemically distinct layers.
- This modularity allows integration of photonic, catalytic, electronic, and bioactive functions without lattice matching.
Purpose of the Study:
- To highlight the transformative potential of 2D vdW nanohybrids in nanomedicine.
- To explore the unique properties and applications of these engineered nanomaterials.
- To position vdW nanohybrids as key components for next-generation therapeutics and diagnostics.
Main Methods:
- Architecting 2D materials into stacked, stitched, or surface-engineered vdW nanohybrids.
- Integrating layers with specific functions like Near Infrared (NIR) light absorption, drug intercalation, and ROS scavenging.
- Utilizing polymeric or biomimetic coatings for enhanced biocompatibility and targeting.
Main Results:
- vdW nanohybrids enable modular integration of photonic, catalytic, electronic, and bioactive functions.
- Applications include photothermal/photodynamic therapy, drug/nucleic acid delivery, and redox modulation.
- 2D vdW interfaces offer advantages over nanoparticles, including maximal surface area and controlled release.
- Synergistic behaviors emerge from vdW stacking, such as photothermal-photodynamic coupling and catalytic-photonic amplification.
Conclusions:
- 2D vdW nanohybrids represent a powerful and versatile material class for nanomedicine.
- Their unique attributes redefine frontiers in therapeutics, diagnostics, regeneration, and bioelectronics.
- These materials are poised to advance next-generation nanomedical applications.
