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A High-Precision Screen-Printed Glucose Sensor with In Situ Impedance-Based HCT Correction and Temperature

Mingxin Lu1, Jie Cheng1, Qinyao Lei1

  • 1School of Automation and Intelligent Sensing, Shanghai Jiao Tong University, Shanghai 200240, China.

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This study introduces a novel glucose sensor that accurately measures blood glucose by correcting for hematocrit (HCT) and temperature variations. This enhances self-monitoring of blood glucose (SMBG) accuracy for diabetic patients.

Keywords:
POCTelectrochemical glucose sensorhematocrit correctionin situ impedance measurementtemperature compensation

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Sensor Technology

Background:

  • Electrochemical glucose test strips for self-monitoring of blood glucose (SMBG) are prone to inaccuracies caused by hematocrit (HCT) fluctuations and ambient temperature variations.
  • These interference factors significantly limit the reliability of blood glucose level measurements in real-world conditions.

Purpose of the Study:

  • To develop a high-precision screen-printed glucose sensor that effectively corrects for both HCT and temperature interferences.
  • To improve the accuracy and stability of glucose measurements in self-monitoring of blood glucose (SMBG) devices.

Main Methods:

  • Development of a screen-printed glucose sensor with integrated in situ impedance-based HCT correction and temperature compensation.
  • Utilizing a time-division multiplexing strategy combined with a normalized thermodynamic model and an HCT correction algorithm for synergistic interference decoupling.
  • Implementing multi-parameter synergistic correction to mitigate temperature and HCT effects.

Main Results:

  • The developed sensor demonstrated excellent stability across a wide temperature range (10-35 °C) and HCT range (10-70%).
  • Post-correction accuracy indicators significantly exceeded ISO 15197:2013 standards, unlike uncorrected measurements which showed deviations from -80% to +30%.
  • The multi-correction strategy effectively resolved systematic errors in whole blood glucose testing without added electrode complexity or pretreatment.

Conclusions:

  • The novel sensor provides a robust technical solution for high-precision, low-cost personal glucose monitoring.
  • This approach effectively addresses critical interference factors in SMBG, paving the way for more reliable blood glucose management.
  • The developed technology offers a significant advancement in the accuracy of electrochemical glucose test strips.