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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Personalized Breast Reconstruction After Breast-Conserving Therapy: Risk-Informed Approaches to Technique Selection

Thomas J Sorenson1, Carter J Boyd1, Rebecca Lisk1

  • 1Hansjorg Wyss Department of Plastic Surgery, NYU-Langone Health, New York, NY 10016, USA.

Journal of Personalized Medicine
|April 27, 2026
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Summary

Personalized breast reconstruction after breast-conserving therapy (BCT) is crucial for improving patient satisfaction. Tailoring techniques to individual risk factors and preferences enhances long-term aesthetic outcomes and minimizes revision surgery.

Keywords:
aestheticbreast conserving therapybreast reconstructionpatient reported outcomespersonalized medicine

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Area of Science:

  • Oncologic surgery
  • Plastic and reconstructive surgery
  • Breast cancer survivorship

Background:

  • Breast-conserving therapy (BCT) offers oncologic outcomes comparable to mastectomy for breast cancer.
  • Aesthetic restoration after BCT is increasingly important, yet reconstructive strategies are less standardized than post-mastectomy.
  • Reconstruction post-BCT faces unique challenges including tissue loss, radiation effects, fibrosis, and varied patient expectations.

Purpose of the Study:

  • To review current reconstructive options following BCT.
  • To emphasize a personalized medicine framework for technique selection, timing, and outcomes.
  • To highlight patient-specific factors influencing reconstructive success.

Main Methods:

  • Literature review synthesizing contemporary reconstructive techniques for BCT.
  • Analysis of patient-specific risk factors (radiation, morphology, comorbidities, prior surgery, psychosocial aspects).
  • Evaluation of oncoplastic volume displacement, implant-based augmentation, fat grafting, and autologous reconstruction in the post-BCT context.

Main Results:

  • Reconstructive techniques must be individualized based on radiation exposure, breast characteristics, and patient factors.
  • Timing of reconstruction and staged procedures significantly impact durability and satisfaction.
  • Revision burden is a critical patient-centered outcome often overlooked by traditional metrics.

Conclusions:

  • A personalized, risk-informed approach with shared decision-making is essential for aligning reconstructive plans with patient goals.
  • Moving beyond technique-focused paradigms to flexible, longitudinal care pathways is necessary.
  • Future research should develop BCT-specific predictive models and incorporate patient-reported outcomes for advanced personalized care.