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Precision Exercise in Type 2 Diabetes Mellitus: Targeting Signaling Networks for Lipid Homeostasis
Tan Tian1, Feiyang Yu1, Xingran Liu2
1School of Sports Training, Wuhan Sports University, Wuhan 430079, China.
Metabolites
|April 27, 2026
Summary
Exercise regulates key signaling pathways involved in lipid metabolism, offering a new approach to manage type 2 diabetes (T2DM) and its complications. Personalized exercise strategies based on molecular profiling can improve T2DM treatment.
Area of Science:
- Molecular biology
- Exercise physiology
- Metabolic disease research
Background:
- Type 2 diabetes mellitus (T2DM) often involves dyslipidemia, worsening insulin resistance and related diseases.
- Current understanding of exercise's molecular mechanisms in T2DM management is incomplete.
Purpose of the Study:
- To propose exercise as a signaling network regulator in T2DM.
- To explore the roles of cAMP, PI3K-AKT, FOXO, and MAPK pathways in T2DM dyslipidemia.
- To present a framework for precision exercise based on molecular profiling.
Main Methods:
- Literature review and synthesis of current evidence.
- Analysis of molecular adaptations to various exercise modalities.
- Integration of signaling pathway dysregulation and exercise effects.
Main Results:
- Exercise modulates cAMP, PI3K-AKT, FOXO, and MAPK signaling pathways crucial for lipid metabolism.
- Dysregulation of these pathways contributes to T2DM-related lipid disorders.
- Different exercise types induce adaptations that restore signaling network homeostasis.
Conclusions:
- Exercise acts as a critical regulator of lipid metabolism signaling networks in T2DM.
- Precision exercise, tailored by molecular profiling, offers a personalized approach to T2DM management.
- This framework enhances understanding of exercise physiology and improves T2DM treatment strategies.
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