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Osteopathic manipulative treatment and cervicogenic headache: a randomized controlled trial
Stephan T Klemm1, Walter Klemm2, Regina Semmler-Ludwig3
1Department of Biomechanics, Leipzig University, St. Andreasberg, Germany.
Journal of Osteopathic Medicine
|April 27, 2026
Summary
Osteopathic manipulative treatment (OMT) significantly improved Neck Disability Index scores for cervicogenic headache (CeH) patients, offering meaningful functional recovery. Patients with greater initial disability experienced the most benefit from OMT.
Area of Science:
- Integrative Medicine
- Neurology
- Musculoskeletal Health
Background:
- Cervicogenic headache (CeH) is a prevalent secondary headache disorder linked to cervical spine dysfunction.
- Understanding effective treatments for CeH is crucial for improving patient outcomes.
Purpose of the Study:
- To investigate the efficacy of osteopathic manipulative treatment (OMT) for managing cervicogenic headache (CeH).
- To assess OMT's impact on functional disability and cervical range of motion in CeH patients.
Main Methods:
- A randomized controlled trial involving 413 CeH patients allocated to OMT or placebo groups.
- Primary outcome: Neck Disability Index (NDI); Secondary outcome: Upper cervical rotation via Flexion-Rotation Test (FRT).
- Statistical analysis included two-factor ANOVAs and Cohen's d for effect size calculation.
Main Results:
- The OMT group showed a significant improvement in NDI scores (5.9 points) compared to the placebo group (2.5 points).
- OMT achieved the minimal clinically important difference (MCID) for NDI, indicating meaningful improvement.
- Large effect sizes (Cohen's d=0.74-0.87) were observed in the OMT group, demonstrating substantial impact.
Conclusions:
- Osteopathic manipulative treatment (OMT) effectively reduces pain and enhances functional capacity in cervicogenic headache (CeH) patients.
- Patients presenting with higher initial Neck Disability Index (NDI) scores derive greater benefits from OMT interventions.

