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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Long-Term Consequences of Preterm Birth: A Lifespan Perspective

Lina F Chalak1, Natalie Vega Ortiz2, Jennifer Joukhdar2

  • 1Division of Neonatal-Perinatal Medicine, Department of Pediatrics, UT Southwestern Medical Center and Children's Medical Center, Dallas, Texas, USA, lina.chalak@utsouthwestern.edu.

Developmental Neuroscience
|April 27, 2026
PubMed

Insights

Preterm birth can lead to accelerated aging, impacting brain and heart health throughout life. Early adversity in preterm infants affects adult health trajectories, increasing risks for cognitive and cardiovascular issues.

Area of Science:

  • Neuroscience
  • Cardiology
  • Developmental Pediatrics
  • Public Health

Background:

  • Preterm birth is a significant factor influencing lifelong health, affecting neurodevelopment, psychiatric conditions, cardiovascular health, and mortality.
  • Early-life adversity, particularly related to prematurity, is linked to accelerated aging of the brain-heart axis.
  • The 'fetus to fifty' model illustrates how early experiences of preterm infants shape their adult health trajectories.

Purpose of the Study:

  • To synthesize evidence on the link between early-life adversity and accelerated aging in the brain-heart axis.
  • To describe the 'fetus to fifty' model and its implications for preterm-born individuals.
  • To identify research gaps and future directions for mitigating premature aging in preterm adults.

Main Methods:

  • Literature review synthesizing current evidence.
  • Description of the 'fetus to fifty' model.
  • Analysis of physiological mechanisms and social determinants.

Main Results:

  • Cardiovascular and neurodevelopmental issues in preterm infants are interconnected.
  • Suboptimal perinatal hemodynamics and inflammation may lead to a shared cardio-cerebral phenotype.
  • Premature cardiovascular aging can compromise cerebrovascular reserve and elevate cognitive decline risk.

Conclusions:

  • The early origins of disease are influenced by biological vulnerability and social determinants.
  • Understanding the interplay between early experiences and lifelong health is crucial.
  • Further research is needed to mitigate premature aging and its associated health risks in preterm-born adults.
Abstract

Keywords:
Cardiac instabilityEarly life adversityNeurodevelopmental outcomesPreterm birth

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