Metal-Organic Frameworks (MOF)-Based Nanozymes: Types, Engineering, and Recent Advances in Biosensing

Area of Science:

• Materials Science
• Nanotechnology
• Biochemistry

Background:

• Nanozymes are nanomaterials with enzyme-like catalytic activity, offering advantages like stability and cost-effectiveness.
• Metal-organic frameworks (MOFs) possess unique structural and compositional properties ideal for mimicking enzyme active sites.
• MOF-based nanozymes represent a significant advancement in biosensor technology.

Purpose of the Study:

• To classify MOF nanozymes according to their catalytic activity.
• To review strategies for enhancing the enzyme-mimicking performance of MOF nanozymes.
• To summarize the applications of MOF nanozymes in the field of biosensing.

Main Methods:

• Classification of MOF nanozymes based on catalytic function.
• Systematic review of methods to improve MOF nanozyme performance.
• Comprehensive survey of MOF nanozyme applications in biosensors.

Main Results:

• MOF nanozymes exhibit diverse catalytic activities, adaptable through rational design.
• Various strategies effectively augment the enzyme-mimicking capabilities of MOF nanozymes.
• MOF nanozymes show significant promise and broad applicability in biosensing.

Conclusions:

• MOF nanozymes offer a versatile platform for developing next-generation biosensors.
• Further research into MOF nanozyme design and application holds great potential.
• Addressing current challenges will pave the way for superior MOF nanozyme performance.