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Related Experiment Video

Updated: Apr 29, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
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Achieving Breast Symmetry After Postmastectomy Radiation Through Contralateral Implant Modification Using Acellular

Alyssa Nguyen1, Colton H Connor1, Claire Fell1

  • 1University of Louisville School of Medicine, KY, USA.

Plastic Surgery (Oakville, Ont.)
|April 28, 2026
PubMed
Summary

This study presents a novel contralateral breast reconstruction technique to correct radiation-induced asymmetry. It avoids operating on the irradiated breast, offering a safe alternative for patients seeking symmetry restoration.

Keywords:
acellular dermal matrixbreast implantbreast reconstructioncapsular contractureradiation fibrosisradiation-induced breast asymmetry

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Area of Science:

  • Plastic Surgery
  • Breast Reconstruction
  • Radiation Oncology

Background:

  • Radiation therapy post-mastectomy can cause breast asymmetry due to fibrosis and capsular contracture.
  • Revising irradiated implant pockets carries high risks of complications, including implant loss.

Purpose of the Study:

  • To present a contralateral reconstructive strategy for radiation-induced breast asymmetry.
  • To offer a safe alternative to operating on irradiated tissue in breast reconstruction.

Main Methods:

  • A case study detailing a contralateral reconstructive approach for radiation-induced breast asymmetry.
  • Utilized a narrow, ultra-high-profile implant with acellular dermal matrix positioned cephalad on the nonirradiated side.

Main Results:

  • Successfully restored symmetry in a patient with severe asymmetry following radiation therapy.
  • Avoided surgical intervention on the irradiated breast, mitigating associated risks.

Conclusions:

  • Contralateral reconstructive surgery is a safe and reproducible option for select patients with radiation-induced breast asymmetry.
  • This technique preserves the irradiated breast's position while achieving aesthetic symmetry.