Jove
Visualize
Contact Us

Related Concept Videos

Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

780
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
780
Tissue Transplantation01:24

Tissue Transplantation

1.4K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.4K
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

630
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
630
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

925
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
925
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

1.7K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.7K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robotic recipient liver transplantation worldwide: a systematic review and meta-analysis of the first 93 patients, from feasibility to early outcomes.

EClinicalMedicine·2026
Same author

Perioperative Prophylaxis in Pediatric Solid Organ Transplantation: A Baseline Stewardship Audit Using Routine Electronic Data.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

Second Report of the American Intestinal Transplant Working Group: New Insights Into Risk Factors, Treatment Regimens, and Outcomes of Malignancy After Intestinal Transplantation.

Transplantation·2026
Same author

Effectiveness of respiratory syncytial virus vaccination in solid organ transplant recipients in the United States.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Protocol for heterotopic mouse intestinal transplantation to study transplant immunology.

STAR protocols·2026
Same author

Donor obesity and MASLD as barriers to living donor liver transplantation: Institutional attrition and national outcomes.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 29, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

4.5K

Invasive Fungal Infections After Intestine Transplantation: Epidemiology and Outcomes.

Mayyadah H Alabdely1, Jessica Lum1, Blanca E Gonzalez2

  • 1Department of Infectious Disease, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Mycoses
|April 28, 2026
PubMed
Summary

Invasive fungal infections (IFIs) are common after intestine transplants, significantly increasing the risk of graft loss or death. Early detection and treatment of IFIs are crucial for better patient outcomes.

Keywords:
IFIallograft lossintestinal transplantoutcomerisk factors

More Related Videos

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

26.7K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

2.6K

Related Experiment Videos

Last Updated: Apr 29, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

4.5K
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

26.7K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

2.6K

Area of Science:

  • Transplantation Medicine
  • Infectious Diseases
  • Gastroenterology

Background:

  • Invasive fungal infections (IFIs) are a significant complication following intestine transplantation, affecting 40-49% of recipients.
  • These infections contribute to high rates of morbidity and allograft loss.

Purpose of the Study:

  • To evaluate the impact of post-transplant IFIs on graft outcomes in intestine transplant recipients.
  • To identify predictors of IFIs and their association with graft failure or mortality.

Main Methods:

  • A retrospective cohort study included 152 intestine transplant recipients between 2008 and 2022.
  • Invasive fungal infection (IFI) was the primary outcome, defined by EORTC/MSGERC criteria.
  • Multivariable Cox proportional hazards models were used to analyze the association between IFIs and allograft failure or death.

Main Results:

  • 36.8% of recipients developed IFIs, with a median onset of 83.5 days post-transplant.
  • Candida species (73%) were the most common IFIs, with significant fluconazole resistance (29.3%).
  • IFI was independently associated with a 3.67-fold increased risk of allograft loss or death (p < 0.001).

Conclusions:

  • Post-transplant IFIs are prevalent and strongly linked to adverse outcomes, including allograft loss and mortality.
  • Early identification and prompt, aggressive management of IFIs are essential for improving survival rates in intestine transplant recipients.