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Updated: Apr 30, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

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CircRbfox1 Contributes to Colonic Hypersensitivity in Rats With Diabetes by Altering HuC Subcellular Localization to

Shiyu Zhang^1,2, Ji Hu¹, Chendong Ni¹

¹Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

CNS Neuroscience & Therapeutics

|April 28, 2026

Summary

This summary is machine-generated.

A novel circular RNA, circRbfox1, is identified as a key player in diabetic colonic hypersensitivity. Its upregulation in diabetic rats promotes visceral pain by influencing protein translation and gene expression, offering a potential therapeutic target.

Keywords:

HuC RBFOX1 circRbfox1 diabetic colonic hypersensitivity dorsal root ganglion

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Published on: September 12, 2019

Area of Science:

Neuroscience
Molecular Biology
Gastroenterology

Background:

Diabetic neuropathy can lead to visceral pain, but the underlying molecular mechanisms remain unclear.
Circular RNAs (circRNAs) are emerging as critical regulators in various biological processes, including pain signaling.

Purpose of the Study:

To elucidate the role of circRNA in mediating colonic hypersensitivity in a rat model of diabetes.
To identify specific circRNAs and their molecular pathways involved in diabetic visceral pain.

Main Methods:

Type 1 Diabetes Mellitus was induced in female rats using streptozotocin.
A combination of molecular biology techniques and behavioral assessments were employed.
The expression and function of circRbfox1 in dorsal root ganglia were investigated.

Main Results:

A novel circRNA, circRbfox1, was identified and found to be significantly upregulated in the dorsal root ganglia of diabetic rats.
circRbfox1 interacts with HuC protein, promoting its nuclear translocation and enhancing RBFOX1 translation.
Increased circRbfox1 expression exacerbates colonic hypersensitivity in diabetic rats by regulating Cav1.3 expression.

Conclusions:

circRbfox1 acts as a crucial regulator of pain in diabetic colonic hypersensitivity.
circRbfox1 represents a potential therapeutic target for managing visceral pain in diabetic patients.