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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

12.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

15.7K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

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Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect...
88
Inflammation01:38

Inflammation

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Overview
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

8.4K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
8.4K
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

53
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
53

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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

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An inflammation memento.

Annalisa M VanHook1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|April 28, 2026
PubMed
Summary
This summary is machine-generated.

Colitis causes epigenetic alterations in colonic stem cells, predisposing them to develop tumors. These changes highlight a critical link between chronic inflammation and cancer initiation.

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Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice
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Area of Science:

  • Gastroenterology and Oncology
  • Epigenetics and Cancer Biology

Background:

  • Colitis, a form of inflammatory bowel disease, is associated with an increased risk of colorectal cancer.
  • Epigenetic modifications play a crucial role in the development of various cancers, including those arising from chronic inflammation.

Purpose of the Study:

  • To investigate the epigenetic changes in colonic stem cells induced by colitis.
  • To determine if these epigenetic alterations prime stem cells for tumor development.

Main Methods:

  • Utilized mouse models of colitis to induce chronic inflammation.
  • Performed genome-wide epigenetic profiling (e.g., DNA methylation, histone modifications) on isolated colonic stem cells.
  • Assessed stem cell function and tumor formation potential in vitro and in vivo.

Main Results:

  • Colitis induced significant and widespread epigenetic reprogramming in colonic stem cells.
  • Specific epigenetic marks were identified that correlated with enhanced stem cell proliferation and survival.
  • These epigenetically altered stem cells exhibited increased tumorigenic potential upon transplantation.

Conclusions:

  • Epigenetic changes driven by colitis act as a crucial mechanism priming colonic stem cells for malignant transformation.
  • Targeting these colitis-induced epigenetic alterations may offer novel therapeutic strategies for preventing or treating colitis-associated colorectal cancer.