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Oxygenic Photosynthesis01:26

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Oxygenic photosynthesis is a fundamental process in which light energy is harnessed to drive the oxidation of water, leading to the production of molecular oxygen (O₂), adenosine triphosphate (ATP), and nicotinamide adenine dinucleotide phosphate (NADPH). This process is essential for sustaining aerobic life on Earth and is primarily carried out by cyanobacteria, algae, and plants. The core of oxygenic photosynthesis lies in the thylakoid membranes, where chlorophyll pigments facilitate...
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This study introduces a novel photocontrolled system for hypoxic tumor therapy. It combines zinc ion release with photoactivated hydride therapy, utilizing a morpholine-modified metalloporphyrin for targeted treatment.

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Area of Science:

  • Biomedical Engineering
  • Photodynamic Therapy
  • Cancer Research

Background:

  • Photocontrolled metal ion release systems for hypoxic tumor therapy are limited.
  • Metalloporphyrins offer photoactivated hydride (H-) therapy under hypoxia.
  • Combining H- therapy with metal ion release remains underexplored.

Purpose of the Study:

  • To develop a novel photocontrolled system for hypoxic tumor therapy.
  • To investigate the combined effect of metal ion release and hydride therapy.
  • To explore the potential of morpholine-modified metalloporphyrin for lysosome-targeted therapy.

Main Methods:

  • Photochemical release of Zn2+ from zinc-coordinated porphyrin (ZnPor).
  • Photoconversion of ZnPor into phlorin (Phl) as a hydride donor.
  • In situ photoactivation of morpholine-modified metalloporphyrin (lysoZnPor) for demetalation.

Main Results:

  • Demonstrated photochemical Zn2+ release and photoconversion to phlorin.
  • Developed a lysosome-targeted hydride therapy using lysoZnPor.
  • Showcased the photoredox cycle harnessing NADH and ubiquinone for cell death induction.

Conclusions:

  • Established a novel pathway for photocontrolled porphyrin demetalation.
  • Highlighted the potential of reductive photodynamic therapy for hypoxic tumors.
  • Validated the efficacy of lysoZnPor in inducing lysosomal dysfunction and cell death.