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Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse
Published on: April 17, 2019
Pilot multicentre open-label randomised controlled trial assessing prevention of recurrent DIverticulitis through the
Muhammad Imran Aumeerally1,2, Christopher Gillespie3, Andrea Warwick3
1Department of Surgery, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia imran.aumeerally@gmail.com.
Introduction:
Despite the ubiquity of diverticular disease, the options for reducing the risk of recurrent diverticulitis remain limited and the pathogenesis remains incompletely understood. While high intraluminal pressures within the distal colon and rectum have been proposed as a possible association with diverticular disease, studies on this relationship have been few, inconsistent and not generalisable. The investigators of this pilot study propose that the repeated transient high intraluminal pressures generated within the distal colon and rectum due to ineffective defecatory technique may predispose some patients to an increased risk of diverticulosis and diverticulitis. Therefore, by correcting defecatory technique through the implementation of pelvic floor physiotherapy (PFPT), the investigators hypothesise that there would be a reduction in the risk of recurrent diverticulitis.
Methods And Analysis:
This pilot multicentre open-label randomised controlled trial will be conducted at Queen Elizabeth II Jubilee Hospital and Logan Hospital in Brisbane, Queensland, Australia. Eligible adult patients admitted with acute diverticulitis will be considered for enrolment and randomised into two groups in a 1:1 allocation ratio. The aim is to recruit 40 patients with 20 patients per group. The control group will receive standard of care dietary advice. The intervention group will receive PFPT as an outpatient within 4 weeks of discharge. The primary endpoint will be the risk of readmission with recurrent diverticulitis within a 12-month follow-up period. Secondary endpoints will be the risk of surgical intervention and/or interventional radiology procedure in the subgroup of patients readmitted with recurrent diverticulitis. Feasibility outcomes will review patient compliance and completeness of data collection. Results of this trial will inform study design and sample size required in a larger prospective study.
Ethics And Dissemination:
Approval was obtained from the Human Research Ethics Committee at the participating centre. Results will be submitted for publication in a peer-reviewed journal.
Trial Registration Number:
ACTRN12625000927426.
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