Long-Term Psychosocial Outcomes in Japanese Mayer-Rokitansky-Küster-Hauser Syndrome: A Single-Center Study

Area of Science:

• Reproductive Medicine
• Gynecology
• Psychosocial Health

Background:

• Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital condition characterized by uterine and vaginal agenesis.
• Vaginal creation is a key treatment to enable sexual intercourse and improve quality of life.
• Long-term psychosocial outcomes of vaginal creation, especially in Japanese populations, require further investigation.

Purpose of the Study:

• To explore the long-term psychosocial outcomes in Japanese patients with MRKH syndrome.
• To analyze the impact of different vaginal creation methods (surgical vs. non-surgical) on psychosocial well-being.
• To identify factors influencing sexual activity, marital status, and psychological adjustment post-treatment.

Main Methods:

• Retrospective review of medical records for 24 MRKH syndrome patients treated between 1987 and 2024.
• Evaluation of choices regarding vaginal creation, sexual activity, marital status, partner disclosure, and psychological well-being.
• Analysis of data from patients who underwent surgical vaginal creation or non-surgical Frank dilation.

Main Results:

• Nineteen patients initiated vaginal creation procedures; 17 successfully formed a neovagina.
• Eleven patients with a neovagina reported sexual intercourse; seven entered into marriage.
• Four patients experienced delayed psychological distress concerning femininity and infertility, including one who declined vaginal creation.

Conclusions:

• Gynecological outpatient care is a vital source of long-term psychosocial support for MRKH syndrome patients.
• Continuous, empathetic follow-up is essential to manage evolving emotional and social challenges beyond the initial treatment phase.
• Addressing concerns about femininity and infertility is critical for comprehensive patient care.