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Engineering and Evolution of Synthetic Adeno-Associated Virus AAV Gene Therapy Vectors via DNA Family Shuffling
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Pool-packaged AAV libraries exhibit extensive length-dependent and homology-dependent chimerism

Jean-Benoît Lalanne1,2, Chau Huynh3,4, John K Mich5

  • 1Department of Genome Sciences, University of Washington, Seattle, WA, USA. jean-benoit.lalanne@umontreal.ca.

Nature Biotechnology
|April 28, 2026
PubMed

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