Related Experiment Video

Updated: Apr 30, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

6.8K

Targeted protein degradation for fetal hemoglobin induction: a new paradigm in β-hemoglobinopathy therapy

Sanjana Arji1,2, Ziyang Shen1, Sabrina Welch1

  • 1Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Biomarker Research
|April 29, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Fetal hemoglobinMolecular glueNanobodyPROTACSickle cell diseaseTargeted protein degradationTreatment optionsβ-hemoglobinopathyβ-thalassemiaγ-globin

More Related Videos

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

11.7K
Mouse Fetal Liver Culture System to Dissect Target Gene Functions at the Early and Late Stages of Terminal Erythropoiesis
06:40

Mouse Fetal Liver Culture System to Dissect Target Gene Functions at the Early and Late Stages of Terminal Erythropoiesis

Published on: September 9, 2014

14.6K

Related Experiment Videos

Last Updated: Apr 30, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

6.8K
High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

11.7K
Mouse Fetal Liver Culture System to Dissect Target Gene Functions at the Early and Late Stages of Terminal Erythropoiesis
06:40

Mouse Fetal Liver Culture System to Dissect Target Gene Functions at the Early and Late Stages of Terminal Erythropoiesis

Published on: September 9, 2014

14.6K

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

81
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
81
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K

Articles linked to this work by shared authors, journal, and citation graph.

Modeling the impacts of budget reductions at the U.S. NIH on research and innovation.

npj health systems·2026

Oligodendrocyte and Astrocyte Dynamics During Short-Term Cuprizone Treatment.

Brain and behavior·2026

Comparative analysis of motixafortide versus plerixafor for stem cell mobilization and collection in multiple myeloma: A single center real-world experience.

Transfusion·2026

Multi-parameter prediction of extubation failure using spontaneous breathing trial and post-spontaneous breathing trial rest period data.

Digital health·2026

A Wearable Motion Capture Dataset for Gait Analysis Using IMUs and Shank-Mounted Egocentric Cameras.

Scientific data·2026

Impact of Dysplasia on Inverted Papilloma Recurrence: A Systematic Review and Meta-Analysis.

International forum of allergy & rhinology·2026

Beyond hypoxia and ccRCC: the expanding universe of VHL novel targets and next-generation therapeutics.

Biomarker research·2026

AI-driven precision immunotherapy: emerging trends from AACR 2026.

Biomarker research·2026

Inflammatory bone marrow microenvironment impairs the therapeutic effect of daratumumab-lenalidomide in multiple myeloma.

Biomarker research·2026

Integrating molecular subtypes, genomics and functional dependencies to identify context-specific therapeutic vulnerabilities in small cell lung cancer.

Biomarker research·2026

LACC1 attenuates LPS-induced acute lung injury by inhibiting inflammatory response in alveolar macrophage through LPAR3/PI3K/AKT/mTOR signaling pathway.

Biomarker research·2026

Pathogens in rheumatoid arthritis: epidemiological, mechanistic, and clinical insights.

Biomarker research·2026

Are Urooncologists Onboard?

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026

The State of the Art of Theranostics and Its Future.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026

[Alzheimer's disease: scientific advances, diagnostic challenges and therapeutic perspectives].

Soins; la revue de reference infirmiere·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us