A multidimensional nomogram integrating immune, inflammatory, and coagulation markers for personalized prognosis in...

ObjectiveTo develop and validate an integrated prognostic model based on tumor immune microenvironmental, systemic inflammatory, and coagulation markers to improve prognostic stratification and personalize management for bladder cancer patients undergoing surgery.MethodsThis retrospective study analyzed 140 patients who underwent radical or partial cystectomy at our institution between 2013 and 2021. Cutoff values for continuous variables were determined using receiver operating characteristic analysis. Independent prognostic factors for overall survival were identified using univariate and multivariate Cox regression analyses. A nomogram was subsequently developed and validated using time-dependent receiver operating characteristic curves, calibration plots, and decision curve analysis.ResultsMultivariate analysis confirmed that tertiary lymphoid structure density, hemoglobin level, D-dimer level, platelet-to-lymphocyte ratio, and clinical stage are independent predictors of overall survival. The constructed nomogram demonstrated high predictive accuracy for 1-, 3-, and 5-year overall survivals, with area under the curve values of 0.868, 0.880, and 0.894, respectively. Calibration and decision curve analyses confirmed the model's excellent consistency and clinical utility. Risk stratification based on the nomogram revealed significant survival differences between the groups (p < 0.001).ConclusionWe developed and validated a novel nomogram that integrates multidimensional immune microenvironmental, systemic inflammatory, and coagulation biomarkers. This model provides a practical tool for prognostic assessment and risk stratification in bladder cancer patients following surgery.