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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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E-based physical exercise in patients with multiple sclerosis and comorbidity (COMPACT): feasibility study and

Rafl Adnan1,2, Sara Samadzadeh1,2,3, Camilla Richter2,4

  • 1Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.

Frontiers in Immunology
|April 29, 2026
PubMed
Summary

Digital physical exercise (PE) shows promise for multiple sclerosis (MS) patients with comorbidities. A randomized controlled trial will assess an e-based PE program

Keywords:
comorbidityfeasibility studymultiple sclerosisphysical exerciserandomized controlled trial

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Digital Health

Background:

  • Comorbidity is common in people with multiple sclerosis (pwMS) and can worsen disease progression.
  • Physical exercise (PE) is known to alleviate MS symptoms and benefit comorbid conditions.
  • Digital (e)-based PE offers a potential solution for integrating exercise into the lives of pwMS.

Purpose of the Study:

  • To outline a randomized controlled trial (RCT) protocol for e-based PE in pwMS.
  • To present feasibility data from a controlled study of an e-based PE intervention for pwMS with and without comorbidities.

Main Methods:

  • A prospective RCT will randomize 300 pwMS (1:1 ratio) to usual care or usual care plus a 6-month home-based e-PE program.
  • The e-PE program involves supervised online resistance training for lower extremities, two 60-minute sessions weekly.
  • Primary outcome is change in walking capacity (6-minute walk test); secondary outcomes include NEDA-3, quality of life, fatigue, and neurofilament light chain levels.

Main Results:

  • Feasibility study (n=50) showed a 91.3% recruitment rate and 63% adherence to the 3-month e-PE program.
  • Participants completed a mean of 15.2 sessions, with no reported intervention-related adverse events.
  • The feasibility study provides a foundation for the larger RCT.

Conclusions:

  • This protocol details a prospective RCT and feasibility data for home-based e-PE in pwMS.
  • The study will evaluate the effects of e-PE, contributing to digital healthcare solutions for MS.
  • The findings are expected to offer significant insights into digital health interventions for managing MS.