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Can dobutamine stress echocardiography predict improvement of left ventricular dyssynchrony after coronary artery

Rezvanieh Salehi1, Zahra Jabbary2, Fariba Abaszadeh1

  • 1Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Caspian Journal of Internal Medicine
|April 29, 2026
PubMed

Insights

Coronary artery bypass grafting (CABG) improved left ventricular ejection fraction in patients with coronary artery disease. However, many patients still experienced left ventricular dyssynchrony, suggesting a need for cardiac resynchronization therapy (CRT).

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Echocardiography

Background:

  • Coronary artery bypass grafting (CABG) is the gold standard for advanced coronary artery disease (CAD).
  • Limited studies assess CABG benefits in patients with left ventricular dyssynchrony (LVD).
  • This study evaluates myocardial viability using dobutamine stress echocardiography (DSE) to predict LVD improvement post-CABG.

Purpose of the Study:

  • To assess the predictive value of viable myocardial tissue volume (quantified by DSE) for postoperative LVD improvement in CABG candidates.
  • To evaluate the impact of CABG on LVD in patients with ischemic cardiomyopathy.

Main Methods:

  • Cross-sectional analytical design involving 30 CABG candidates with moderate-severe ischemic cardiomyopathy.
  • Dobutamine stress echocardiography (DSE) for myocardial viability assessment.
  • Tissue Doppler Imaging (TDI) for synchronized assessment of regional left ventricular (LV) contractility.

Main Results:

  • The study population averaged 61.5±7.9 years, with 73.3% males.
  • Left ventricular ejection fraction (LVEF) improved significantly post-CABG (32.2±4.6% to 39.6±5.2%, p<0.001).
  • Postoperative LVD resolution occurred in 30% of patients; 63.3% showed no significant improvement (p<0.001).

Conclusions:

  • CABG leads to significant postoperative improvements in LVEF and LVD.
  • Approximately two-thirds of patients experienced minimal improvement in LVD post-CABG.
  • Cardiac resynchronization therapy (CRT) should be considered for patients with persistent LVD after CABG.
Abstract

Keywords:
Left ventricular dyssynchronyCoronary artery bypass graftingDobutamine stress echocardiography

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