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Related Concept Videos

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Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
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Nanopores with dynamic pore opening diameter.

Savannah Silva1, Xavier Mleziva2,3, Anthony Dougman Cho1

  • 1Department of Physics and Astronomy, University of California, Irvine, Irvine, CA 92697, USA. zsiwy@uci.edu.

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|April 29, 2026
PubMed
Summary
This summary is machine-generated.

Researchers created dynamic solid-state nanopores with DNA to mimic biological channels. These DNA-nanopore systems exhibit tunable memristor-like behavior, paving the way for novel electronic devices.

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Area of Science:

  • Nanotechnology
  • Biophysics
  • Materials Science

Background:

  • Solid-state nanopores are static, limiting their applications.
  • Dynamic nanopores could enable new transport modes and electronic devices.
  • Biological channels offer inspiration for dynamic pore systems.

Purpose of the Study:

  • To create and characterize dynamic solid-state nanopores.
  • To investigate DNA-nanopore interactions under electric fields.
  • To explore memristor-like behavior in nanoconfined DNA.

Main Methods:

  • Fabrication of ~10 nm nanopores in gold/silicon nitride films.
  • Functionalization with single-stranded DNA or DNA hairpins using thiol chemistry.
  • Electrical measurements of current-voltage curves under varying conditions.
  • Brownian dynamics simulations to model DNA behavior.

Main Results:

  • Nanopores with single-stranded DNA showed memristor-like behavior with tunable hysteresis.
  • DNA hairpin nanopores exhibited symmetric current-voltage curves due to molecular rigidity.
  • Simulations confirmed voltage and salt concentration effects on DNA extension.
  • DNA extension depended on its position within the nanopore.

Conclusions:

  • Dynamic nanopores with DNA can be fabricated and controlled.
  • Memristor-like behavior arises from nanoconfined DNA's response to electric fields.
  • These systems represent a step towards non-equilibrium nanopore devices.