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Updated: Apr 30, 2026

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Roles of AKR1C1 in Non-small Cell Lung Cancer

Xinran Zhang1, Qi Zhang1, Yuting Chang1

  • 1Department of Oncology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, 225300 Taizhou, Jiangsu, China.

Frontiers in Bioscience (Landmark Edition)
|April 29, 2026
PubMed

Insights

Aberrant aldo-keto reductase 1C1 (AKR1C1) expression is linked to lung squamous cell carcinoma (LUSC) progression. Targeting AKR1C1 may offer a new therapeutic strategy for LUSC by modulating ferroptosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Non-small cell lung cancer (NSCLC), particularly lung squamous cell carcinoma (LUSC), has high global incidence and mortality.
  • Current targeted therapies and immunotherapies are ineffective for a majority of LUSC patients lacking actionable mutations.
  • Chemotherapy remains a primary treatment for LUSC but has limited efficacy and significant toxicity.

Purpose of the Study:

  • To investigate the role of aldo-keto reductase family 1 member C1 (AKR1C1) in LUSC.
  • To explore the potential of targeting AKR1C1 as a therapeutic strategy for LUSC by modulating ferroptosis.

Main Methods:

  • Analysis of aberrant AKR1C1 expression in LUSC.
  • Investigating the association between AKR1C1 and tumor progression, invasiveness, and prognosis.
  • Exploring the implication of AKR1C1 in ferroptosis pathways.

Main Results:

  • Aberrant AKR1C1 expression is strongly associated with tumor progression, invasiveness, and poor prognosis in several cancers, including potentially LUSC.
  • AKR1C1 is implicated in ferroptosis, a regulated cell death pathway.

Conclusions:

  • Targeting AKR1C1 may represent a novel therapeutic approach for LUSC.
  • Modulating ferroptosis pathways via AKR1C1 inhibition could impact LUSC cell proliferation.
Keywords:
carcinomaferroptosismetabolismmolecular targeted therapynon-small-cell lung

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