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Home-Based RESIST: Rationale and Design of a Multicenter Randomized Controlled Trial.

Wanwan Zhang1, Yuanyuan Liu1, Wanying Zhang1

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Summary
This summary is machine-generated.

Home-based exercise may reduce recurrent strokes in patients with symptomatic intracranial artery stenosis (sICAS). The RESIST trial investigates structured physical activity versus usual care to improve outcomes and safety for sICAS patients.

Keywords:
home basedintracranial atherosclerotic stenosisischemic strokephysical exercisetransient ischemic attack

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Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Rehabilitation Medicine

Background:

  • Symptomatic intracranial artery stenosis (sICAS) carries a high risk of recurrent stroke despite medical treatment.
  • Physical exercise is linked to reduced stroke recurrence, but evidence for its superiority in sICAS is limited.
  • Gym-based exercise poses challenges for long-term adherence, necessitating home-based alternatives.

Purpose of the Study:

  • To evaluate the effectiveness and safety of home-based structured physical exercise combined with usual care compared to usual care alone in preventing recurrent strokes in sICAS patients.
  • To assess the impact of this intervention on various secondary stroke-related outcomes and cognitive function.

Main Methods:

  • The RESIST trial is a multicenter, prospective, randomized, controlled, open-label, blinded endpoint assessment study in China.
  • 1300 patients with recent sICAS will be randomized 1:1 to either home-based structured exercise plus usual care or usual care.
  • Primary outcome is new ischemic stroke within 1 year; secondary outcomes include stroke/TIA, MI, functional status (mRS), quality of life (EQ-5D-5L), and cognition (MoCA).

Main Results:

  • This section is not yet available as the study is ongoing.

Conclusions:

  • The RESIST trial is expected to provide critical evidence on the efficacy and safety of home-based structured physical exercise for secondary stroke prevention in sICAS.
  • Findings will inform clinical practice regarding non-pharmacological interventions for managing sICAS and reducing stroke recurrence.