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Biocompatible Zinc-4,4'-bipyridine-Based One-Dimensional Metal-Organic Framework with Unique Structural Features and

Ankita Saha1, Bani Preet Kaur2, Richa Rani Gupta2

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|April 29, 2026
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Summary

A novel zinc-based metal-organic framework (MOF), NBU-7, demonstrates potent antibacterial properties against various bacterial strains. This biocompatible material shows low toxicity, offering a promising solution for combating drug-resistant diseases.

Keywords:
Escherichia coliStaphylococcus aureusZn(II) MOFantibacterial activitycytocompatibilityhemocompatibilitysingle-crystal X-ray diffractionwater-stable

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Area of Science:

  • Materials Science
  • Chemistry
  • Biotechnology

Background:

  • Drug-resistant diseases pose a significant global health threat, increasing mortality and healthcare costs.
  • Developing biocompatible materials with antibacterial properties is crucial for combating resistance.
  • Metal-organic frameworks (MOFs), particularly zinc-based ones, show promise as antibacterial agents.

Purpose of the Study:

  • To synthesize and characterize a novel zinc-based 1D MOF, NBU-7.
  • To evaluate the antibacterial efficacy and cytotoxicity of NBU-7.
  • To explore the mechanism of antibacterial action of NBU-7.

Main Methods:

  • Facile solvothermal synthesis of NBU-7.
  • Structural characterization using X-ray diffraction, spectroscopy, and elemental analysis.
  • Antibacterial evaluation including minimum inhibitory concentration (MIC) and cell viability assays.
  • Cytotoxicity assessment using mammalian fibroblasts (L929) and hemolysis assays.
  • Scanning Electron Microscopy (SEM) for visualizing bacterial cell membrane interaction.

Main Results:

  • Successful synthesis and characterization of the 1D Zn-MOF, NBU-7.
  • NBU-7 exhibits good water solubility and stability.
  • Low MIC values and reduced bacterial viability against Gram-negative and Gram-positive bacteria.
  • Minimal cytotoxicity towards L929 fibroblasts and a hemolytic rate below 5%.
  • SEM analysis indicates NBU-7 ruptures bacterial cell membranes, leading to lysis.

Conclusions:

  • NBU-7 is a promising biocompatible zinc-based MOF with significant antibacterial activity.
  • The MOF effectively targets and lyses bacterial cells with low mammalian cell toxicity.
  • NBU-7 presents a potential therapeutic agent for addressing the challenge of drug-resistant infections.