Biocompatible Zinc-4,4'-bipyridine-Based One-Dimensional Metal-Organic Framework with Unique Structural Features and...

Increased mortality and escalating healthcare expenses are two major consequences of the ever-growing peril to global health posed by drug-resistant diseases in recent times. To combat these problems, it is crucial to develop suitable biocompatible materials that possess potential antibacterial properties. In this context, metal-organic frameworks are emerging candidates in overcoming antibacterial resistance, especially those composed of zinc. Herein, we report the synthesis, characterisation, and subsequent antibacterial evaluation of a zinc and 4,4'-bipyridine-based, 1D MOF, NBU-7, employing a facile solvothermal method. X-ray diffraction studies divulge the structural facets of the MOF, while spectroscopic and analytical details further augment the successful formation of the MOF. NBU-7 also displays good solubility and stability in water with low minimum inhibitory concentrations and reduced cell viability against Gram-negative and Gram-positive bacterial strains. Further, NBU-7 shows minimal cytotoxicity towards mammalian fibroblasts (L929), while SEM analysis reveals the ability of the Zn-MOF to rupture the bacterial cell membrane, leading to lysis. Additionally, the hemolysis assay with variable concentrations showed insignificant deviation from normal saline, depicting a hemolytic rate below 5%. These findings render NBU-7 MOF as a potential agent for antibacterial applications.