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Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
Secondary metabolites from the mangrove endophytic fungus Curvularia sp. P3
Huan-Yan Liu1, Xi-Kang Zheng1, Xiao-Rao Chen1
1Guangdong Provincial Key Laboratory of Natural Drugs Research and Development, Dongguan Key Laboratory for Marine Innovative Drugs and Bioproducts, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Abstract:
A new nonribosomal peptide-polyketide (NRP-PK) hybrid, curvularisin (1), and a new polyketide, spiciferone D (2), together with twelve known compounds (3 - 14), were isolated from the mangrove-derived endophytic fungus Curvularia sp. P3. Their structures were established through extensive NMR and HRMS analyses, and the absolute configuration of 2 was confirmed by ECD comparison. Cytotoxicity evaluation on five cancer cell lines (4T1, HeLa, A549, Caco-2, and LLC) revealed a promising activity of compound 13 against LLC (IC50 = 5.9 μM), and a moderate effect of compound 12 against Caco-2 (IC50 = 49.2 μM). Additionally, compound 13 inhibited the growth of several bacterial strains, with MIC values ranging from 32 to 64 μg/ml.
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