Integrating Histologic Descriptors Into the Ninth Edition TNM Staging Improves Prognostic Stratification of Lung
Hanie Abolfathi1, Michael Maranda-Robitaille2, Fabien Claude Lamaze2
1Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada; Department of Molecular Medicine, Université Laval, Quebec City, Canada.
Introduction:
Histologic descriptors such as lymphovascular invasion (LVI), visceral pleural invasion (VPI), spread through air spaces (STAS), and histologic grade have each been associated with adverse outcomes in lung adenocarcinoma. However, with the exception of VPI, these features are not formally incorporated into the TNM staging system. We evaluated the prognostic value and incremental contribution of these histologic descriptors within the framework of the ninth edition TNM staging system.
Methods:
In total, 1745 individuals diagnosed with stages I to III invasive nonmucinous lung adenocarcinoma were included in this study, comprising 1139 French-Canadian patients who underwent surgical resection at the IUCPQ-Université Laval (discovery cohort) and 606 patients from the National Cancer Center Hospital in Tokyo, Japan (validation cohort). The objective of this study was to assess the prognostic contribution of histologic descriptors, including histologic grade, STAS, and LVI, as complements to conventional ninth edition TNM staging.
Results:
Grade 3 tumors, LVI, and STAS were identified in 880 (50.4%), 809 (46.4%), and 775 (44.4%) of 1745 cases, respectively. Histologic grade and LVI demonstrated the strongest associations, particularly in early stage disease, whereas STAS exhibited a stage-dependent effect, being more impactful in stages II to III. VPI had less consistent prognostic value. Incorporating these histologic descriptors into TNM staging improved prognostic model performance, with the largest gains driven by histologic grade and LVI, whereas STAS provided modest complementary prognostic refinement.
Conclusion:
These findings demonstrate that key histologic descriptors-including histologic grade, LVI, and STAS-represent robust and consistent prognostic parameters. Importantly, these descriptors provide complementary, stage-dependent information that may enhance risk stratification and inform refinement of future TNM staging frameworks, including the forthcoming tenth edition.
