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Steroid receptor coactivators in immunity - From function to emerging translational opportunities
1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
The Journal of Biological Chemistry
|April 29, 2026
Summary
Steroid Receptor Coactivators (SRCs) are crucial for gene regulation and impact health and disease. Small-molecule modulators now offer new therapeutic strategies by targeting SRCs for cancer and immune responses.
Area of Science:
- Molecular Biology
- Genetics
- Immunology
Background:
- Steroid Receptor Coactivators (SRCs) are essential transcriptional coactivators for nuclear receptors (NRs) and other transcription factors (TFs).
- SRCs play a vital role in numerous physiological and pathological processes, including development, reproduction, metabolism, immunity, and cancer.
- Targeting SRCs therapeutically has been challenging for nearly two decades.
Purpose of the Study:
- To review the central roles of SRCs in normal physiology and cancer.
- To outline the development of small-molecule modulators for SRC activity.
- To discuss the functions of SRCs in immunity and their therapeutic potential.
Main Methods:
- Literature review of SRC functions in gene regulation, physiology, and disease.
- Analysis of the development and application of small-molecule SRC modulators.
- Examination of SRC involvement in immune responses and therapeutic strategies.
Main Results:
- SRCs are critical regulators of gene transcription, impacting diverse biological processes.
- Small-molecule modulators have been developed, enabling SRC targeting in cancer.
- Unexpected immunomodulatory effects of SRC modulation reveal broader therapeutic potential.
Conclusions:
- SRCs are key players in both cancer and immune system regulation.
- Pharmacological targeting and genetic manipulation of SRCs can reshape immune responses.
- Targeting SRCs presents promising new therapeutic strategies for cancer and other diseases, particularly those involving immune dysregulation.
Keywords:
ImmunologyT cell biologyTh17 cellsTreg cellsdrug discoveryhormone receptorssmall molecule drugs steroid receptor coactivators (SRC)More Related Videos
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