Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunostimulation with bacterial phospholipid extracts.

R M Fauve, B Hevin

    Proceedings of the National Academy of Sciences of the United States of America
    |February 1, 1974
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Quantitation of messenger RNA by competitive RT-PCR: a simplified read out assay.

    Journal of immunological methods·1998
    Same author

    The anti-tumoral activity of human glycoprotein HGP.92: a study with the mouse Lewis-lung-tumor cell.

    International journal of cancer·1997
    Same author

    The biology of macrophages.

    Pathologie-biologie·1997
    Same author

    Purification of a 92 kDa human immunostimulating glycoprotein obtained from the Tamm-Horsfall glycoprotein.

    Journal of immunological methods·1995
    Same author

    Human glycoprotein HGP92 induces cytokine synthesis in mouse mononuclear phagocytes.

    International immunology·1995
    Same author

    A 92-kDa human immunostimulatory protein.

    Proceedings of the National Academy of Sciences of the United States of America·1994
    Same journal

    Costunolide ameliorates autoimmune uveitis by targeting USP15 to suppress TNF-α-induced retinal endothelial inflammation.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    A ligandable PNT domain establishes ERG as a directly targetable oncogenic driver in prostate cancer.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Identification of cellular intermediates unveils unique enzymes for flagellar glycan biosynthesis in <i>Clostridioides difficile</i>.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    The structure of correlated variability reflects task-relevant information in sensory neurons.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Shared neurogenetic substrates of nonplanning impulsivity and procrastination.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    HIV-1 capsid interactions with Nuclear Pore Complex components support nuclear entry via affinity gradient.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    See all related articles

    Bacterial phospholipid extracts (EBP) enhance host resistance against Listeria monocytogenes and Salmonella typhimurium infections in mice. This immunostimulant shows no apparent toxicity, distinguishing it from other bacterial stimulants.

    Area of Science:

    • Immunology
    • Microbiology
    • Pharmacology

    Background:

    • Bacterial components are known to modulate host immune responses.
    • Developing effective and non-toxic immunostimulants is crucial for combating bacterial infections.

    Purpose of the Study:

    • To investigate the effects of bacterial phospholipid extracts (EBP) on host resistance against bacterial infections.
    • To evaluate the safety profile of EBP as a potential immunostimulant.

    Main Methods:

    • Mice were injected with varying doses of EBP.
    • Resistance to Listeria monocytogenes infection was assessed.
    • Blood clearance of Salmonella typhimurium was measured.
    • Organ burdens of Listeria monocytogenes in spleen and liver were quantified.

    Related Experiment Videos

  • Potential toxicity, including organomegaly and lymphoid hyperplasia, was examined.

    • Main Results:

    • EBP injection significantly increased resistance to Listeria monocytogenes infection in mice.
    • Enhanced blood clearance of Salmonella typhimurium was observed, correlating with EBP dosage.
    • Multiplication of Listeria monocytogenes in the spleen and liver was inhibited, dose-dependently.
    • No apparent toxicity, splenohepatomegaly, or lymphoid hyperplasia was detected in EBP-treated mice.

    Conclusions:

    • Bacterial phospholipid extracts (EBP) act as effective immunostimulants, enhancing host resistance against Gram-negative and Gram-positive bacterial infections.
    • EBP demonstrates a favorable safety profile, differentiating it from other bacterial immunostimulants.
    • EBP represents a promising candidate for further development as a therapeutic agent against bacterial infections.