Related Experiment Video

Updated: May 1, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

14.3K

Long-Term Outcomes in Children With Congenital Cytomegalovirus Infection

Noriko Morimoto1, Noriomi Suzuki1, Kanako Imamura1

  • 1Department of Otolaryngology National Center for Child Health and Development Tokyo Japan.

Laryngoscope Investigative Otolaryngology
|April 30, 2026
PubMed

Insights

Early antiviral therapy with valganciclovir (VGCV) for congenital cytomegalovirus (cCMV) infection in children may stabilize hearing. This intervention appears to reduce long-term hearing deterioration, emphasizing the importance of prompt treatment.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Audiology

Background:

  • Congenital cytomegalovirus (cCMV) infection is a leading cause of non-genetic sensorineural hearing loss in children.
  • Long-term auditory outcomes in cCMV-infected children, particularly those treated with antivirals, require further investigation.

Purpose of the Study:

  • To evaluate the long-term effects of early antiviral therapy, specifically valganciclovir (VGCV), on auditory outcomes in children with cCMV infection.
  • To assess hearing loss progression and age of onset in treated versus untreated cCMV patients.

Main Methods:

  • A retrospective cohort study of 56 pediatric patients with cCMV infection.
  • Comparison of audiological assessments between a VGCV-treated group (n=19) and an untreated group (n=37) over a minimum 2-year follow-up.
  • Definition of significant hearing decline as ≥10 dB loss.

Main Results:

  • While overall prevalence and severity of hearing loss did not differ significantly, the VGCV-treated group showed significantly less hearing deterioration (26% vs. 41%, p<0.01).
  • The magnitude of hearing decline was substantially smaller in the treated group (35.0±13.8 dB) compared to the untreated group (67.4±19.2 dB, p<0.002).
  • Hearing loss stabilized by age 3 in treated children, whereas untreated children experienced recurrent hearing deterioration.

Conclusions:

  • Early VGCV treatment for cCMV infection may stabilize hearing and mitigate long-term auditory damage in children.
  • Prompt intervention and consistent hearing surveillance are crucial for managing cCMV-related hearing loss, especially in untreated cases.
Abstract

Keywords:
antiviral therapycongenital cytomegaloviruslong‐term outcomespediatric hearing lossvalganciclovir

More Related Videos

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

19.1K
A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

928

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.7K
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
360