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Updated: May 1, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Lipoprotein(a) and acute myocardial infarction: Differential risk across age and sex subgroups

Zhe Liu1, Hui Li2, Wen Chang3

  • 1Department of Cardiology, Taixing People's Hospital, China.

The Journal of International Medical Research
|April 30, 2026
PubMed

Insights

High lipoprotein(a) levels significantly increase acute myocardial infarction risk, particularly in older women. This highlights lipoprotein(a) as a potential target for lipid-lowering therapies in this specific demographic.

Area of Science:

  • Cardiology
  • Genetics
  • Epidemiology

Background:

  • Lipoprotein(a) is a known risk factor for acute myocardial infarction (AMI).
  • The role of lipoprotein(a) in specific patient subgroups requires further investigation.
  • Classical risk factors may modify the association between lipoprotein(a) and AMI.

Purpose of the Study:

  • To investigate the association between lipoprotein(a) levels and acute myocardial infarction (AMI).
  • To determine if classical risk factors modify this association across different subgroups.
  • To identify specific populations where lipoprotein(a) poses a higher risk for AMI.

Main Methods:

  • A case-control study involving 2946 AMI patients and 14,571 controls.
  • Data analyzed using multiple imputation and propensity score-based matching.
  • Binary logistic regression, stratification, and sensitivity analyses were employed.

Main Results:

  • Higher lipoprotein(a) levels were observed in the AMI group.
  • Adjusted analysis showed increased odds ratios for AMI with higher lipoprotein(a) quartiles.
  • The association was significantly stronger in older patients and female participants, especially older women.

Conclusions:

  • High lipoprotein(a) levels are an independent risk factor for initial acute myocardial infarction.
  • The risk associated with high lipoprotein(a) is amplified in older women.
  • Lipoprotein(a) represents a potential therapeutic target for lipid-lowering interventions in older women at risk for AMI.

Keywords:
Lipoprotein(a)acute myocardial infarctionmultiple imputationolder femalespropensity score-based matchingrisk factor

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