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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Related Experiment Video

Updated: Jun 28, 2026

A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells
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A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells

Published on: August 22, 2025

MID: A Self-Supervised Multimodal Iterative Denoising Framework.

Chang Nie, Tianchen Deng, Zhe Liu

    IEEE Transactions on Neural Networks and Learning Systems
    |April 30, 2026
    PubMed
    Summary
    This summary is machine-generated.

    We introduce MID, a self-supervised denoising framework that works across different data types. This method effectively removes complex noise from images and signals using only corrupted data, proving robust and broadly applicable.

    Related Experiment Videos

    Last Updated: Jun 28, 2026

    A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells
    10:37

    A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells

    Published on: August 22, 2025

    Area of Science:

    • Computer Vision
    • Biomedicine
    • Bioinformatics
    • Signal Processing

    Background:

    • Denoising is crucial for vision, medical, and biological applications.
    • Real-world data often suffers from complex nonlinear noise.
    • Clean target data is frequently unavailable for training.

    Purpose of the Study:

    • To present MID, a self-supervised iterative denoising framework adaptable across data modalities.
    • To enable effective denoising using only noisy observations, addressing the lack of clean targets.

    Main Methods:

    • MID models observations as intermediate states in a controllable corruption process.
    • It employs two networks: a step predictor for corruption stage estimation and a residual predictor for noise removal.
    • A first-order local approximation handles nonlinear corruption by enabling iterative restoration in a locally linear regime.

    Main Results:

    • MID demonstrates robustness and broad applicability across diverse tasks.
    • Experiments in computer vision, biomedicine, and bioinformatics show competitive performance against existing methods.
    • The framework successfully denoises images, signals, point sets, and sequences.

    Conclusions:

    • MID offers a versatile and effective self-supervised approach to denoising.
    • The framework's ability to handle nonlinear noise and work across modalities makes it highly valuable.
    • MID presents a significant advancement in self-supervised learning for data restoration.