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Recovery of cardiac function in Desmin cardiomyopathy with medical therapy

Mengdi Yu1, Lutong Pu1, Jie Wang2,3

  • 1Department of Cardiology, West China Hospital, Sichuan University, Guoxue Alley No. 37, Chengdu, Sichuan, 610041, China.

Orphanet Journal of Rare Diseases
|May 1, 2026
PubMed

Insights

Desmin cardiomyopathy, a genetic heart condition, was diagnosed in a young man via genetic testing and cardiac MRI. Treatment with guideline-directed medical therapy and vericiguat led to normalized heart function.

Area of Science:

  • Cardiology
  • Genetics
  • Cardiovascular Imaging

Background:

  • Desmin cardiomyopathy is a rare genetic heart condition caused by DES gene variants.
  • It presents with diverse phenotypes and often has a poor prognosis.
Abstract

Keywords:
CRYABCardiomyopathyCardiovascular magnetic resonanceDesminHeart failure

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