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Scalp nodular syphilis：Case illustrated.
Xiaopan Gong1, Xiaoyu Su1, Qin Mei1
1Department of Dermatology, Fuzhou Dermatology Hospital, Fuzhou, Fujian 35000, China.
Idcases
|May 1, 2026
Summary
Secondary syphilis can manifest as asymptomatic scalp nodules in adults. Diagnosis involves histopathology and serological tests like TPPA and RPR, with treatment leading to resolution.
Area of Science:
- Dermatology
- Infectious Diseases
- Syphilology
Background:
- Secondary syphilis is a systemic stage of syphilis infection.
- Cutaneous manifestations are common but can be atypical.
- Scalp involvement in secondary syphilis is rare but possible.
Purpose of the Study:
- To report a case of secondary syphilis presenting as asymptomatic scalp nodules.
- To highlight the importance of considering syphilis in differential diagnoses for scalp lesions.
Main Methods:
- A case presentation of a 32-year-old male with persistent scalp nodules.
- Diagnostic workup included histopathological examination and serological tests: Treponema pallidum particle agglutination (TPPA) and rapid plasma reagin (RPR).
- Treatment response was monitored for confirmation of diagnosis.
Main Results:
- Histopathology was performed on scalp nodules.
- Serological tests revealed a positive Treponema pallidum particle agglutination (TPPA) and a rapid plasma reagin (RPR) titer of 1:32.
- The patient's scalp nodules resolved completely following appropriate treatment.
Conclusions:
- Asymptomatic scalp nodules can be a presentation of secondary syphilis.
- Early diagnosis and treatment are crucial for managing syphilis.
- This case underscores the diverse clinical presentations of syphilis.
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