Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

1.3K
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K
Heart Valves01:16

Heart Valves

14.9K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
14.9K
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

1.6K
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
1.6K
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

686
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
686
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

1.4K
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
1.4K
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

1.1K
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small Mitral Valve Orifice Area in Mitral Valve Transcatheter Edge-to-Edge Repair: The REPAIR Study.

JACC. Advances·2026
Same author

Prognostic Implications of RV-Arterial Coupling Estimated by CMR in a Large Cohort of Tricuspid Regurgitation Patients.

Circulation. Cardiovascular imaging·2026
Same author

Right Ventricular Metrics as End Points in Clinical Trials: A Review.

JAMA cardiology·2026
Same author

Longitudinal event-sampling dataset of football fans across five countries during the 2024 European championship.

Scientific data·2026
Same author

Impact of pre-existing CIED on mid-term mortality in patients undergoing TAVR.

Clinical research in cardiology : official journal of the German Cardiac Society·2026
Same author

Autonomic modulation in functional tricuspid regurgitation: effects of transcatheter valve repair.

Heart and vessels·2026

Related Experiment Video

Updated: May 2, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

3.7K

Focus on tricuspid valve-the European perspective.

Helge Möllmann1, Marcel Weber2, Maria Isabel Körber3

  • 1Medizinische Klinik I, St. Johannes Hospital Dortmund, Dortmund, Germany.

European Heart Journal Supplements : Journal of the European Society of Cardiology
|May 1, 2026
PubMed
Summary

Transcatheter tricuspid valve repair (TTVR) offers a promising alternative for treating tricuspid regurgitation (TR) in elderly patients. Initial results show lower mortality than surgery, but procedural success and adverse events require further investigation.

Keywords:
Heart failureInterventional treatmentTEERTricuspid regurgitationValve implantation

More Related Videos

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

2.0K
Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

16.0K

Related Experiment Videos

Last Updated: May 2, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

3.7K
Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

2.0K
Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

16.0K

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Tricuspid regurgitation (TR) affects 4% of individuals over 75, increasing heart failure morbidity and hospitalizations.
  • The prevalence of TR is rising in Europe due to an aging population, straining heart failure services.
  • Traditional surgical TR repair/replacement is underutilized due to high operative risks (8.0%-12.3% mortality).

Purpose of the Study:

  • To evaluate the initial outcomes of transcatheter therapies for tricuspid regurgitation (TR).
  • To compare the safety and efficacy of transcatheter TR treatments with historical surgical outcomes.
  • To identify the most utilized transcatheter devices for TR intervention.

Main Methods:

  • Review of initial results from various transcatheter tricuspid valve repair (TTVR) and replacement (TTVR) devices.
  • Analysis of procedural success rates, 30-day all-cause mortality, and major adverse events.
  • Comparison of TTVR outcomes against historical data for isolated tricuspid valve surgery.

Main Results:

  • Transcatheter therapies demonstrated promising 30-day all-cause mortality of 3.7%, significantly lower than surgical mortality.
  • Procedural success was achieved in 62% of cases, with major adverse events occurring in 26%.
  • Transcatheter edge-to-edge repair (T-TEER) was the predominant intervention, despite off-label use of some devices.

Conclusions:

  • Transcatheter TR therapies represent a paradigm shift, offering a less invasive option for high-risk patients.
  • While mortality is lower, procedural success rates and adverse event profiles necessitate further research and device refinement.
  • The landscape of TR treatment is rapidly evolving with multiple device options, T-TEER being the most common currently.