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Dual-Lead Spinal Cord Stimulation for Refractory Diabetic Small Fiber Neuropathy With Erythromelalgia-Like Features:

Jared Spivey1, Joseph A McGuire1, Eric Jonswold2

  • 1West Virginia University School of Medicine, Department of Anesthesiology, Morgantown, WV.

Pain Medicine Case Reports
|May 1, 2026
PubMed
Summary

Spinal cord stimulation may effectively treat painful diabetic small fiber neuropathy with erythromelalgia-like symptoms. This neuromodulation approach improved pain and autonomic dysfunction in a patient with refractory symptoms.

Keywords:
Recurrent tachycardiaanticoagulationconduction blockglaucomahematomahigh-riskmyocardial infarctionregionalropivacainestellate ganglion

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Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...