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Updated: May 3, 2026

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
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Editor's Highlights-June 2026.

Lajos Kemény1

  • 1Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.

International Journal of Dermatology
|May 2, 2026
PubMed
Summary
This summary is machine-generated.

New therapies are expanding treatment options for inflammatory skin conditions. Recent approvals include TYK2 inhibitors and IL-23 antagonists for psoriasis, while IL-4Rα inhibitors show promise for atopic dermatitis, and GLP-1 RAs are explored for hidradenitis suppurativa.

Keywords:
GLP‐1 receptor agonistsTYK2atopic dermatitisdepressionhidradenitis suppurativaicotrokinraobesitypsoriasisstapokibart

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Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Significant advancements are reshaping the treatment paradigms for inflammatory skin diseases.
  • The therapeutic landscape for conditions like psoriasis, atopic dermatitis, and hidradenitis suppurativa is rapidly evolving.

Purpose of the Study:

  • To provide an overview of recent therapeutic advances in major inflammatory skin diseases.
  • To highlight novel drug approvals and emerging treatment strategies.

Main Methods:

  • Review of recent clinical trial data and regulatory approvals.
  • Analysis of emerging therapeutic targets and drug classes.

Main Results:

  • The United States Food and Drug Administration (FDA) approved deucravacitinib (a tyrosine kinase 2 inhibitor) and icotrokinra (an oral interleukin-23 receptor antagonist peptide) for psoriasis.
  • Stapokibart, an interleukin-4 receptor alpha subunit (IL-4Rα) inhibitor, has emerged as a new treatment in China for atopic dermatitis.
  • Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are gaining attention as adjunctive therapy for hidradenitis suppurativa.

Conclusions:

  • The development of targeted therapies has significantly expanded treatment options for inflammatory skin diseases.
  • Ongoing research continues to identify novel therapeutic targets and drug candidates for dermatological conditions.